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We are an adventurous basic science research lab at UCSF. We investigate the impact of gene regulation on health and disease. We value curiosity-driven fundamental scientific investigation both for its impact on our understanding of the natural world and for its unanticipated utility.


Silencing:
chromatin and RNA

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We study how information in DNA is controlled. We are particularly interested in the nucleosome because it is the fundamental unit of chromatin, the form of DNA that exists in the nucleus. Modifications of the nucleosome, some of which are heritable, enable the specialization of chromosomal regions for their functions. Defects in these mechanisms underlie numerous diseases including cancer. Key mechanisms under study include the two conserved forms of heterochromatin (H3K9me and H3K27me), DNA methylation (5mC), and RNAi. We seek answers to the fundamental questions of how domains are chosen for silencing, its mechanistic underpinnings, and its biological impact. We use powerful yeast systems (Schizosaccharomyces pombe and Cryptococcus neoformans) that have maintained these mechanisms to address key unanswered questions. For more information click here.

#genomics #DNA methylation #Polycomb #HP1 #RNAi #genome defense

Infectious Disease: Cryptococcus neoformans

Fungal infectious are among the most difficult to diagnose and treat clinically. The yeast Cryptococcus neoformans a leading cause of lethal fungal infections, particularly in immunocompromised individuals. The Madhani Lab has extensively developed this yeast as a powerful model organism enabling studies of the mechanisms underlying fungal pathogenesis and drug responses. For more information click here.

#Cryptococcus #virulence #quorum sensing #phagocytosis #virulence

 

News

July 1, 2017
Janine Sengstack joins the lab for a summer rotation. She will be working with Diana Summers on the Qsp1 project


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